|By PR Newswire||
|February 20, 2014 12:01 PM EST||
BOULDER, Colo., Feb. 20, 2014 /PRNewswire/ -- Significant attention has been given to methods of shielding human space participants from radiation on missions. But what if some astronauts suffer from susceptible DNA before entering the space radiation environment? Two American scientists have proposed that certain astronaut molecular profiles may 1) reduce inherent DNA stability, 2) slow DNA repair, and 3) render DNA more susceptible to mutational events when exposed to the radiation of space.
Michael A. Schmidt, Ph.D. (Sovaris Aerospace) and Thomas J. Goodwin, Ph.D. (NASA Johnson Space Center) have identified a novel approach to space radiation countermeasures, which is based on understanding the DNA stability, DNA repair capability, and oxidative susceptibility of individual astronauts before they enter the space environment. This methodology is linked to individual genotype and micronutrient status, both of which are potentially modifiable by appropriate pre-flight and in-flight countermeasures.
For instance, common gene mutations affecting one carbon metabolism (MTHFR, MTR, MTRR) may result in the build-up of a faulty base (uracil) within the DNA backbone. This can lead to single strand DNA breaks and double strand DNA breaks, before astronauts enter space. The effect of this is amplified by folate and B12 deficiency.
Other common gene mutations (Hfe) trigger excessive iron accumulation, which creates unstable DNA through oxidative stress mechanisms, also before entering space. Magnesium is a central atom in most DNA repair enzymes. Significant serum, urine, and muscle loss of Mg has already been found in ISS astronauts on long missions, thus raising the question about whether we are already flying some astronauts with diminished capacity to repair DNA damage.
According to Schmidt, "We are examining how individual molecular influences affect DNA stability and repair before astronauts enter the elevated radiation conditions of space, and then how to manage those influences while they live in space. But we are looking well beyond DNA and into the vast network of molecular influences on astronaut physiology. We and our colleagues are using genomics, transcriptomics, proteomics, and metabolomics to develop a platform for personalized medicine that will guide the present and future of human space flight. As the field evolves, we expect to increasingly be able to individualize countermeasures, so that each astronaut receives the protocol that is most suitable to him or her. This will be crucial for missions to the Moon, Mars, and beyond. Of equal importance, we use what we've learned from the complexity of space to translate these benefits to earth-based medicine."
Goodwin states, "In the end, it is about advancing the science and about developing solutions, which we see evolving in phases. Our goal, at minimum, includes: (1) establish the criteria for ''best evidence'' that can be used to develop individualized countermeasures today; (2) establish the criteria for best evidence that prioritizes research, clinical assessment, and individualized countermeasures to be developed in the near term; and (3) establish a deliberate discovery path that seeks to develop sophisticated and more complex models for long-term deployment of personalized medicine, as the future standard of preparation and care in human space flight."
Their paper, entitled Personalized Medicine in Human Space Flight: Using Omics Based Analyses to Develop Individualized Countermeasures that Enhance Astronaut Safety and Performance, was recently published in the journal Metabolomics (Schmidt, MA, Goodwin, TJ. Metabolomics Dec 2013;9(6):1134-1156).
Michael A. Schmidt, Ph.D. is co-chair of the Advanced Pattern Analysis & Countermeasures Group. He and his team have ongoing collaborations with NASA Ames Research Center, NASA Johnson Space Center, and commercial space flight companies that are focused on human missions to the ISS, Moon, Mars, and elsewhere. Dr. Schmidt is the founder of Sovaris Aerospace, LLC and Chairman of MetaboLogics, LLC, based at the Infectious Disease Research Complex at Colorado State University. Sovaris Aerospace, LLC uses pattern analysis, signal processing, and predictive modeling to develop molecular/physiologic assessment and countermeasure solutions for humans in space. MetaboLogics, LLC, applies these methods to earth-based medicine.
Thomas J. Goodwin, Ph.D. is Manager of the Disease Modeling & Tissue Analogues Laboratory, Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center.
SOURCE Sovaris Aerospace, LLC
Customer experience has become a competitive differentiator for companies, and it’s imperative that brands seamlessly connect the customer journey across all platforms. With the continued explosion of IoT, join us for a look at how to build a winning digital foundation in the connected era – today and in the future. In his session at @ThingsExpo, Chris Nguyen, Group Product Marketing Manager at Adobe, will discuss how to successfully leverage mobile, rapidly deploy content, capture real-time d...
May. 31, 2016 01:45 PM EDT Reads: 1,783
SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in Embedded and IoT solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology, is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/Big Data, HPC and ...
May. 31, 2016 01:15 PM EDT Reads: 928
18th Cloud Expo, taking place June 7-9, 2016, at the Javits Center in New York City, NY, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Meanwhile, 94% of enterprises are using some...
May. 31, 2016 01:00 PM EDT Reads: 3,285
What a difference a year makes. Organizations aren’t just talking about IoT possibilities, it is now baked into their core business strategy. With IoT, billions of devices generating data from different companies on different networks around the globe need to interact. From efficiency to better customer insights to completely new business models, IoT will turn traditional business models upside down. In the new customer-centric age, the key to success is delivering critical services and apps wit...
May. 31, 2016 12:30 PM EDT Reads: 1,390
As cloud and storage projections continue to rise, the number of organizations moving to the cloud is escalating and it is clear cloud storage is here to stay. However, is it secure? Data is the lifeblood for government entities, countries, cloud service providers and enterprises alike and losing or exposing that data can have disastrous results. There are new concepts for data storage on the horizon that will deliver secure solutions for storing and moving sensitive data around the world. ...
May. 31, 2016 12:00 PM EDT Reads: 1,502
Join us at Cloud Expo | @ThingsExpo 2016 – June 7-9 at the Javits Center in New York City and November 1-3 at the Santa Clara Convention Center in Santa Clara, CA – and deliver your unique message in a way that is striking and unforgettable by taking advantage of SYS-CON's unmatched high-impact, result-driven event / media packages.
May. 31, 2016 12:00 PM EDT Reads: 2,616
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, will provide an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life ...
May. 31, 2016 11:45 AM EDT Reads: 2,123
SYS-CON Events announced today that IBM Cloud Data Services has been named “Bronze Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. IBM Cloud Data Services offers a portfolio of integrated, best-of-breed cloud data services for developers focused on mobile computing and analytics use cases.
May. 31, 2016 11:30 AM EDT Reads: 1,670
Cloud computing delivers on-demand resources that provide businesses with flexibility and cost-savings. The challenge in moving workloads to the cloud has been the cost and complexity of ensuring the initial and ongoing security and regulatory (PCI, HIPAA, FFIEC) compliance across private and public clouds. Manual security compliance is slow, prone to human error, and represents over 50% of the cost of managing cloud applications. Determining how to automate cloud security compliance is critical...
May. 31, 2016 11:00 AM EDT Reads: 1,928
SYS-CON Events announced today that MobiDev will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MobiDev is a software company that develops and delivers turn-key mobile apps, websites, web services, and complex software systems for startups and enterprises. Since 2009 it has grown from a small group of passionate engineers and business managers to a full-scale mobile software company with over 200 develope...
May. 31, 2016 10:15 AM EDT Reads: 2,915
SoftLayer operates a global cloud infrastructure platform built for Internet scale. With a global footprint of data centers and network points of presence, SoftLayer provides infrastructure as a service to leading-edge customers ranging from Web startups to global enterprises. SoftLayer's modular architecture, full-featured API, and sophisticated automation provide unparalleled performance and control. Its flexible unified platform seamlessly spans physical and virtual devices linked via a world...
May. 31, 2016 09:00 AM EDT Reads: 2,441
SYS-CON Events announced today that BMC Software has been named "Siver Sponsor" of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2015 at the Javits Center in New York, New York. BMC is a global leader in innovative software solutions that help businesses transform into digital enterprises for the ultimate competitive advantage. BMC Digital Enterprise Management is a set of innovative IT solutions designed to make digital business fast, seamless, and optimized from mainframe to mo...
May. 31, 2016 08:45 AM EDT Reads: 2,421
"What we see what happens when you have a completely networked society and the potential to now drive the value creation and the collaboration and the ecosystems that are possible when you start to be able to connect people and industries together in ways that have never been possible before," explained Esmeralda Swartz, VP of Marketing Enterprise & Cloud at Ericsson, in this SYS-CON.tv interview at @ThingsExpo, held November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA.
May. 31, 2016 08:15 AM EDT Reads: 1,855
Companies can harness IoT and predictive analytics to sustain business continuity; predict and manage site performance during emergencies; minimize expensive reactive maintenance; and forecast equipment and maintenance budgets and expenditures. Providing cost-effective, uninterrupted service is challenging, particularly for organizations with geographically dispersed operations.
May. 31, 2016 08:00 AM EDT Reads: 2,356
The Internet of Things (IoT) is growing rapidly by extending current technologies, products and networks. By 2020, Cisco estimates there will be 50 billion connected devices. Gartner has forecast revenues of over $300 billion, just to IoT suppliers. Now is the time to figure out how you’ll make money – not just create innovative products. With hundreds of new products and companies jumping into the IoT fray every month, there’s no shortage of innovation. Despite this, McKinsey/VisionMobile data...
May. 31, 2016 07:45 AM EDT Reads: 1,857
The IoTs will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform. In his session at @ThingsExpo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm and share the must-have mindsets for removing complexity from the development proc...
May. 31, 2016 06:00 AM EDT Reads: 2,040
SYS-CON Events announced today TechTarget has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. TechTarget is the Web’s leading destination for serious technology buyers researching and making enterprise technology decisions. Its extensive global networ...
May. 31, 2016 05:45 AM EDT Reads: 3,385
SYS-CON Events announced today that MangoApps will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device. For more information, please visit https://www.mangoapps.com/.
May. 31, 2016 05:45 AM EDT Reads: 1,224
SYS-CON Events announced today that Commvault, a global leader in enterprise data protection and information management, has been named “Bronze Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY, and the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Commvault is a leading provider of data protection and information management...
May. 31, 2016 05:00 AM EDT Reads: 3,381
The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
May. 31, 2016 04:30 AM EDT Reads: 1,604